ABSTRACT
Objective To investigate the relationship between diabetic retinopathy(DR) and serum vitamin D in patients with type 2 diabetes mellitus (T2DM).Methods A total of 310 patients with T2DM both managed in the bio-bank and the diabetes management system of Center for Disease Control and Prevention of Minhang District during Feb.,2012 to Dec.,2014 were selected.Then 205 patients were divided into non diabetic retinopathy group (NDR) and 105 patients into DR group according to the fundus examinations.The patients' demographical information,medical history and laboratory essays were collected,serum 25 (OH)D levels were detected.Results Single factor analysis indicated that,compared with NDR group,25(OH)D level of DR group decreased(t =3.465,P＜0.001),prevalence of 25(OH)D deficiency rose (x2 =5.313,P =0.021),however,prevalence of 25 (OH) D insufficiency showed no statistical significance (x2 =0.990,P =0.320).Binary Logistic regression analyses showed the inverse correlation between 25 (OH)D level and DR (OR =0.954,95％CI:0.926-0.983,P =0.002),in addition,the risk for DR in T2DM patients who were deficient in 25 (OH)D was 2.17 times than those who were not (OR =2.171,95％ CI:1.047-4.500,P =0.037),after adjusting for a number of variables (demographics,medical history,fasting plasma glucose,postprandial blood glucose,triglyceride and uric acid).Conclusions Serum 25 (OH)D level was negatively related with DR in patients with T2DM.25 (OH)D deficiency might be relevant to the risk of type 2 diabetic retinopathy.
ABSTRACT
Objective To understand the characteristics and disease burden of the hospitalized injuries in hospitals of Minhang District of Shanghai,and to provide evidence-based analysis for policy making.Methods Hospitalized injury cases from 2012 to 2016 were collected from the online registry portal of general hospitals in Minhang area.The International Classification of Diseases (ICD-10) was referred in this study to discuss the characteristics and diseases burden of injury incidents.Results A total of 18 208 cases were collected including 61.83％ males and 38.17％ females.The females were 10 years older than males on average.There were differences among age groups:46.84％of the injury occurred in 40-64 years old cases,28.95％ occurred in 15-39 years old and 23.64％ occurred in people above 65.Less damage occurred under 15 years old,just accounting for 0.57％.The first three injury causes in the list of all were falls (53.83％),transport accidents (13.30％) and accidents (11.86％).The average hospital stay was 10 days and medical expenses was 17 241.24 RMB.The hospital stay and medical expenses were longer and more expensive in female than in male.The top five reasons for medical expenses were accidents,falls,undetermined intent,transport accidents and machinery injury.According to the hospital discharge record,48.65％ of the patients recovered,42.50％ improved,6.17％ did not improve and 1.44％ died.Most injury cases caused by accidents were recovered,and the death rate of injury cases caused by transport accidents was the highest.Conclusions Middle-aged people were the key group for injury prevention strategy.Females were characterized by long-time hospitalization,high cost and better results,while males were characterized by the high incidents,high mortality and poor prognosis.The characteristics in age and types of injuries should be taken into account for injury prevention strategy.
ABSTRACT
Objective To analyze the incidence trend of malignant tumor in Minhang District of Shanghai from 2002 to 2013,in order to provide scientific evidence for making the comprehensive prevention and control strategy.Methods Incidence of cancer data (2002-2013) of Minhang District were collected.The crude rate,standardized rate,sectional shrinkage rate,accumulation rate,percentage change (PC),annual percentage change (APC) and annual change contribution rate were calculated for main malignant tumors separately.Results The total incidence of malignant tumors in Minhang District from 2002 to 2013 increased year by year,mainly showed in thyroid cancer,colorectal cancer and breast cancer,while decreased in gastric cancer,liver cancer and lung cancer.Conclusions The incidence of malignant tumor in Minhang District was increasing.The incidence of thyroid cancer,colorectal cancer and breast cancer were significantly increased,which were needed to pay more attention.The incidence of gastric cancer and liver cancer were decreased significantly,which indicated that exposure factors were controlled effectively.
ABSTRACT
Objective To investigate the risk of overall and site-specific cancers in Chinese patients with type 2 diabetes mellitus (T2DM) in Minhang District of Shanghai.Methods A population-based retrospective cohort study including 51 372 T2DM patients was conducted in Minhang District,Shanghai from 2004 to 2014.All T2DM patients were enrolled from the standardized management system based on local electronic information system of Shanghai.Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry.Standardized incidence ratios (SIR) and 95％CI were used to estimate the risk of cancers among T2DM patients.Results Overall crude incidence rate (CIR) of cancers was 969.69 per 105 person-years in men and 834.17 per 105 person-years in women.The age-standardized rate (ASR [W]) was 206.72 per 105 person-years in men and 285.80 per 105 person-years in women.Increased risk of cancer was found in both sex,with an SIR of 0.93 (95％CI:0.88-0.98) in men and 1.07 (95％ CI:1.01-1.12) in women.Conclusions Our results indicate that patients with T2DM may have an increased risk of some cancers,and the increase may vary by sub-sites of cancers.
ABSTRACT
<p><b>BACKGROUND</b>Currently, treatment of symptomatic polycystic liver disease (PLD) is still a challenging problem, especially for these patients who are not feasible for surgery. Minimally invasive options such as laparoscopic fenestration and percutaneous cyst aspiration with sclerotherapy demonstrated disappointing results due to multiple lesions. Because the cysts in PLD are mostly supplied from hepatic arteries but not from portal veins, transcatheter arterial embolization (TAE) of the hepatic artery branches that supply the major hepatic cysts can lead to shrinkage of the cyst and liver size, relieve symptoms, and improve nutritional status. This study aimed to evaluate the effectiveness of TAE with a mixture of N-butyl-2-cyanoacrylate (NBCA) and iodized oil for patients with severe symptomatic PLD during a more than 2-year follow-up.</p><p><b>METHODS</b>Institutional review board had approved this study. Written informed consent was obtained from all patients. From February 2007 to December 2014, twenty-three patients (20 women and 3 men; mean age, 49.0 ± 14.5 years) infeasible for surgical treatments underwent TAE. Changes in the abdominal circumferences, volumes of intrahepatic cysts, hepatic parenchyma volume, and whole liver, clinical symptoms, laboratory data, and complications were evaluated after TAE.</p><p><b>RESULTS</b>Technical success was achieved in all cases. No procedure-related major complications occurred. The median follow-up period after TAE was 48.5 months (interquartile range, 30.0-72.0 months). PLD-related severe symptoms were improved remarkably in 86% of the treated patients; TAE failed to benefit in four patients (four patients did not benefit from TAE). The mean maximum abdominal circumference decreased significantly from 106.0 ± 8.0 cm to 87.0 ± 15.0 cm (P = 0.021). The mean intrahepatic cystic volume reduction rates compared with pre-TAE were 36% at 12 months, 37% at 24 months, and 38% at 36 months after TAE (P < 0.05). The mean liver volume reduction rates were 32% at 12 months, 31% at 24 months, and 33% at 36 months (P < 0.05).</p><p><b>CONCLUSIONS</b>TAE with the mixture of NBCA and iodized oil appears to be a safe and effective treatment method for patients with symptomatic PLD, especially for those who are not good candidates for surgical treatments, to improve both hepatic volume and hepatic cysts volume.</p>
ABSTRACT
Objective To investigate the relationship between diabetic retinopathy(DR) and serum vitamin D in patients with type 2 diabetes mellitus (T2DM).Methods A total of 310 patients with T2DM both managed in the bio-bank and the diabetes management system of Center for Disease Control and Prevention of Minhang District during Feb.,2012 to Dec.,2014 were selected.Then 205 patients were divided into non diabetic retinopathy group (NDR) and 105 patients into DR group according to the fundus examinations.The patients' demographical information,medical history and laboratory essays were collected,serum 25 (OH)D levels were detected.Results Single factor analysis indicated that,compared with NDR group,25(OH)D level of DR group decreased(t =3.465,P＜0.001),prevalence of 25(OH)D deficiency rose (x2 =5.313,P =0.021),however,prevalence of 25 (OH) D insufficiency showed no statistical significance (x2 =0.990,P =0.320).Binary Logistic regression analyses showed the inverse correlation between 25 (OH)D level and DR (OR =0.954,95％CI:0.926-0.983,P =0.002),in addition,the risk for DR in T2DM patients who were deficient in 25 (OH)D was 2.17 times than those who were not (OR =2.171,95％ CI:1.047-4.500,P =0.037),after adjusting for a number of variables (demographics,medical history,fasting plasma glucose,postprandial blood glucose,triglyceride and uric acid).Conclusions Serum 25 (OH)D level was negatively related with DR in patients with T2DM.25 (OH)D deficiency might be relevant to the risk of type 2 diabetic retinopathy.
ABSTRACT
Objective To understand the characteristics and disease burden of the hospitalized injuries in hospitals of Minhang District of Shanghai,and to provide evidence-based analysis for policy making.Methods Hospitalized injury cases from 2012 to 2016 were collected from the online registry portal of general hospitals in Minhang area.The International Classification of Diseases (ICD-10) was referred in this study to discuss the characteristics and diseases burden of injury incidents.Results A total of 18 208 cases were collected including 61.83％ males and 38.17％ females.The females were 10 years older than males on average.There were differences among age groups:46.84％of the injury occurred in 40-64 years old cases,28.95％ occurred in 15-39 years old and 23.64％ occurred in people above 65.Less damage occurred under 15 years old,just accounting for 0.57％.The first three injury causes in the list of all were falls (53.83％),transport accidents (13.30％) and accidents (11.86％).The average hospital stay was 10 days and medical expenses was 17 241.24 RMB.The hospital stay and medical expenses were longer and more expensive in female than in male.The top five reasons for medical expenses were accidents,falls,undetermined intent,transport accidents and machinery injury.According to the hospital discharge record,48.65％ of the patients recovered,42.50％ improved,6.17％ did not improve and 1.44％ died.Most injury cases caused by accidents were recovered,and the death rate of injury cases caused by transport accidents was the highest.Conclusions Middle-aged people were the key group for injury prevention strategy.Females were characterized by long-time hospitalization,high cost and better results,while males were characterized by the high incidents,high mortality and poor prognosis.The characteristics in age and types of injuries should be taken into account for injury prevention strategy.
ABSTRACT
Objective To analyze the incidence trend of malignant tumor in Minhang District of Shanghai from 2002 to 2013,in order to provide scientific evidence for making the comprehensive prevention and control strategy.Methods Incidence of cancer data (2002-2013) of Minhang District were collected.The crude rate,standardized rate,sectional shrinkage rate,accumulation rate,percentage change (PC),annual percentage change (APC) and annual change contribution rate were calculated for main malignant tumors separately.Results The total incidence of malignant tumors in Minhang District from 2002 to 2013 increased year by year,mainly showed in thyroid cancer,colorectal cancer and breast cancer,while decreased in gastric cancer,liver cancer and lung cancer.Conclusions The incidence of malignant tumor in Minhang District was increasing.The incidence of thyroid cancer,colorectal cancer and breast cancer were significantly increased,which were needed to pay more attention.The incidence of gastric cancer and liver cancer were decreased significantly,which indicated that exposure factors were controlled effectively.
ABSTRACT
Objective To investigate the risk of overall and site-specific cancers in Chinese patients with type 2 diabetes mellitus (T2DM) in Minhang District of Shanghai.Methods A population-based retrospective cohort study including 51 372 T2DM patients was conducted in Minhang District,Shanghai from 2004 to 2014.All T2DM patients were enrolled from the standardized management system based on local electronic information system of Shanghai.Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry.Standardized incidence ratios (SIR) and 95％CI were used to estimate the risk of cancers among T2DM patients.Results Overall crude incidence rate (CIR) of cancers was 969.69 per 105 person-years in men and 834.17 per 105 person-years in women.The age-standardized rate (ASR [W]) was 206.72 per 105 person-years in men and 285.80 per 105 person-years in women.Increased risk of cancer was found in both sex,with an SIR of 0.93 (95％CI:0.88-0.98) in men and 1.07 (95％ CI:1.01-1.12) in women.Conclusions Our results indicate that patients with T2DM may have an increased risk of some cancers,and the increase may vary by sub-sites of cancers.